Na,K-ATPase α1 and β-subunits show distinct localizations in the nervous tissue of the large milkweed bug.

ABSTRACT: The Na,K-ATPase (NKA) is an essential ion transporter and signaling molecule in all animal tissues and believed to consist at least one α and one ß-subunit to form a functional enzyme. In the large milkweed bug, Oncopeltus fasciatus, adaptation to dietary cardiac glycosides (CGs), which can fatally block the NKA, has resulted in gene duplications leading to four α1-subunits. These differ in sensitivity to CGs, but resistance trades off against ion pumping activity, thus influencing the α1-subunits' suitability for specific tissues. Besides, O. fasciatus possesses four different ß-subunits that can alter the NKA's kinetics and should play an essential role in the formation of cellular junctions.Proteomic analyses revealed the distribution and composition of α1/ß-complexes in the nervous tis

SUBMITTER: Herbertz M 

PROVIDER: S-EPMC9110512 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature