Context dependent differences in working memory related brain activity in heavy cannabis users.

ABSTRACT:

Rationale

Compromised cognitive control in cannabis use-tempting situations is thought to play a key role in the development of cannabis use disorders. However, little is known about how exposure to cannabis cues and contexts may influence cognitive control and the underlying neural mechanisms in cannabis users.

Objectives

Working memory (WM) is an attention reliant executive function central to cognitive control. In this study, we investigated how distracting cannabis words affected WM load-dependent performance and related brain activity in near-daily cannabis users (N = 36) relative to controls (N = 33).

Methods

Brain activity was recorded during a novel N-back flanker WM task with neutral and cannabis flankers added as task-irrelevant distractors.

Results

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SUBMITTER: Kroon E 

PROVIDER: S-EPMC9110519 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature