Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects.

ABSTRACT:

Rationale

Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-tetrahydrocannabinol (THC) on SID.

Objectives

The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID.

Methods

THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for

SUBMITTER: Fuentes-Verdugo E 

PROVIDER: S-EPMC9110535 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature