The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.

ABSTRACT: Polygenic risk scores (PRSs) aggregate the effects of genetic variants across the genome and are used to predict risk of complex diseases, such as obesity. Current PRSs only include common variants (minor allele frequency (MAF) ≥1%), whereas the contribution of rare variants in PRSs to predict disease remains unknown. Here, we examine whether augmenting the standard common variant PRS (PRS_common) with a rare variant PRS (PRS_rare) improves prediction of obesity. We used genome-wide genotyped and imputed data on 451,145 European-ancestry participants of the UK Biobank, as well as whole exome sequencing (WES) data on 184,385 participants. We performed single variant analyses (for both common and rare variants) and gene-based analyses (for rare variants) for association w

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9110787 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature