Alterations of Lysine Acetylation Profile in Murine Skeletal Muscles Upon Exercise.

ABSTRACT:

Objective

Regular exercise is a powerful tool that enhances skeletal muscle mass and strength. Lysine acetylation is an important post-translational modification (PTM) involved in a broad array of cellular functions. Skeletal muscle protein contains a considerable number of lysine-acetylated (Kac) sites, so we aimed to investigate the effects of exercise-induced lysine acetylation on skeletal muscle proteins.

Methods

We randomly divided 20 male C57BL/6 mice into exercise and control groups. After 6 weeks of treadmill exercise, a lysine acetylation proteomics analysis of the gastrocnemius muscles of mice was performed.

Results

A total of 2,254 lysine acetylation sites in 693 protein groups were identified, among which 1,916 sites in 528 proteins were quantified. The en

SUBMITTER: Liang D 

PROVIDER: S-EPMC9110802 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature