Chronic Kidney Failure Provokes the Enrichment of Terminally Differentiated CD8⁺ T Cells, Impairing Cytotoxic Mechanisms After Kidney Transplantation.

ABSTRACT: Chronic kidney failure (KF) provokes the development of immune senescent CD8⁺ cytotoxic T cells, affecting the occurrence of graft rejection, viral infections, and malignancies after kidney transplantation. In this study, we analyzed the impact of KF, subsequent dialysis treatment, and kidney transplantation on the differentiation of CD8⁺CD31⁺CD45RA⁺CCR7⁺ recent thymic emigrant (CCR7⁺ RTE) Tregs/Tresps into CD8⁺CD31^-CD45RA^- memory (CD31^- memory) Tregs/Tresps and its effect on the release of cytokines, Fas receptor, Fas ligand as well as cytotoxic mediators by naïve, central memory (CM), effector memory (EM), and terminally differentiated effector memory (TEMRA) Tresps. We found tha

SUBMITTER: Leonhard J 

PROVIDER: S-EPMC9110814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature