Quantification of the Landscape for Revealing the Underlying Mechanism of Intestinal-Type Gastric Cancer.

ABSTRACT: Gastric cancer is a daunting disease with a tragic impact on global health. It is the fourth most common cancer and has become the second most frequent cause of cancer death in recent times. According to the Lauren classification, gastric cancer can be classified into two types: intestinal and diffuse. Intestinal-type gastric cancer (IGC) is more common in elderly people, and atrophic gastritis (AG) and intestinal metaplasia (IM) have been proven to be the main premalignant causes of intestinal-type gastric cancer. In turn, Helicobacter pylori infection has been identified as the most significant cause of AG and IM. In this study, we determine the mechanism of IGC progression and how H. pylori infection induces IGC. Through researching the relevant literature, we identified t

SUBMITTER: Yu C 

PROVIDER: S-EPMC9110827 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature