What's Shape Got to Do With It? Examining the Relationship Between Facial Shape and Orofacial Clefting.

ABSTRACT: Nonsyndromic orofacial clefts belong to a class of congenital malformations characterized by a complex and multifactorial etiology. During early facial development, multiple factors can disrupt fusion leading to a cleft; this includes the shape of the embryonic face. The face shape hypothesis (FSH) of orofacial clefting emerged in the 1960s, influenced by morphological differences observed within affected families, comparative studies of mouse models, and advances in modeling genetic liability for complex traits in populations. For the past five decades, studies have documented changes in the shape or spatial arrangement of facial prominences in embryonic mice and altered post-natal facial shape in individuals at elevated risk for orofacial clefting due to their family history. Moreover, r

SUBMITTER: Weinberg SM 

PROVIDER: S-EPMC9111168 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature