Efficacy of pharmacological interventions in COVID-19: A network meta-analysis.

ABSTRACT:

Aims

To perform network meta-analysis for a head-to-head comparison of various interventions used in coronavirus disease 2019 (COVID-19) on mortality, clinical recovery, time to clinical improvement and the occurrence of serious adverse events.

Methods

Systematic search was performed using online databases with suitable MeSH terms including coronavirus, COVID-19, randomized controlled trial, hydroxychloroquine, lopinavir/ritonavir, tocilizumab, remdesivir, favipiravir, dexamethasone and interferon-β. Data were independently extracted by 2 study investigators and analysed.

Results

Out of 1225 studies screened, 23 were included for qualitative and quantitative analysis. Among the drugs studied, dexamethasone reduces mortality by 10%, with a relative risk of 0.90 (95% co

SUBMITTER: Selvarajan S 

PROVIDER: S-EPMC9111227 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature