Interdependencies of cellular and humoral immune responses in heterologous and homologous SARS-CoV-2 vaccination.

ABSTRACT:

Background

Homologous and heterologous SARS-CoV-2 vaccinations yield different spike protein-directed humoral and cellular immune responses. This study aimed to explore their currently unknown interdependencies.

Methods

COV-ADAPT is a prospective, observational cohort study of 417 healthcare workers who received vaccination with homologous ChAdOx1 nCoV-19, homologous BNT162b2 or with heterologous ChAdOx1 nCoV-19/BNT162b2. We assessed humoral (anti-spike-RBD-IgG, neutralizing antibodies, and avidity) and cellular (spike-induced T-cell interferon-γ release) immune responses in blood samples up to 2 weeks before (T1) and 2-12 weeks following secondary immunization (T2).

Results

Initial vaccination with ChAdOx1 nCoV-19 resulted in lower anti-spike-RBD-IgG compared with BN

SUBMITTER: Hollstein MM 

PROVIDER: S-EPMC9111248 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature