Association of smoking, lung function and COPD in COVID-19 risk: a two-step Mendelian randomization study.

ABSTRACT:

Background and aims

Smoking increases the risk of severe COVID-19, but whether lung function or chronic obstructive pulmonary disease (COPD) mediate the underlying associations is unclear. We conducted the largest Mendelian randomization study to date, to our knowledge, to address these questions.

Design

Mendelian randomization study using summary statistics from genome-wide association studies (GWAS), FinnGen and UK Biobank. The main analysis was the inverse variance weighted method, and we included a range of sensitivity analyses to assess the robustness of the findings.

Setting

GWAS which included international consortia, FinnGen and UK Biobank.

Participants

The sample size ranged from 193 638 to 2 586 691.

Measurements

Genetic determinants of life-ti

SUBMITTER: Au Yeung SL 

PROVIDER: S-EPMC9111410 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature