Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.

ABSTRACT:

Background

Several autoimmune features occur during coronavirus disease 2019 (COVID-19), with possible implications for disease course, immunity, and autoimmune pathology. In this study, we longitudinally screened for clinically relevant systemic autoantibodies to assess their prevalence, temporal trajectory, and association with immunity, comorbidities, and severity of COVID-19.

Methods

We performed highly sensitive indirect immunofluorescence assays to detect antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibodies (ANCA), along with serum proteomics and virome-wide serological profiling in a multicentric cohort of 175 COVID-19 patients followed up to 1 year after infection, eleven vaccinated individuals, and 41 unexposed controls.

Results

Compared wit

SUBMITTER: Taeschler P 

PROVIDER: S-EPMC9111424 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature