Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies.

ABSTRACT:

Background

Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is associated with different domains of language impairments. Here, we aim to provide a comprehensive overview of neuroanatomical basis in post-stroke aphasia through coordinate based meta-analysis of voxel-based lesion-symptom mapping studies.

Methods

We performed a meta-analysis of lesion-symptom mapping studies in post-stroke aphasia. We obtained coordinate-based structural neuroimaging data for 2,007 individuals with aphasia from 25 studies that met predefined inclusion criteria.

Results

Overall, our results revealed that th

SUBMITTER: Na Y 

PROVIDER: S-EPMC9112051 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature