Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice.

ABSTRACT:

Background and purpose

Excess nutrient-induced endothelial cell inflammation is a hallmark of high fat diet (HFD)-induced metabolic syndrome. Pharmacological activation of the protein kinase AMP-activated α1 (PRKAA1) also known as AMPKα1, shows its beneficial effects in many studies of cardiometabolic disorders. However, AMPKα1, as a major cellular sensor of energy and nutrients in endothelial cells, has not been studied for its physiological role in excess nutrient-induced endothelial cell (EC) inflammation.

Experimental approach

Wild-type and EC-specific Prkaa1 knockout mice were fed with an HFD. Body weight, fat mass composition, glucose, and lipid levels were monitored regularly. Insulin sensitivity was analysed systemically and in major metabolic organs/tissues. Inflamm

SUBMITTER: Yang Q 

PROVIDER: S-EPMC9112062 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature