Association of Adjuvant or Metastatic Setting With Discontinuation of Cancer Drugs in Clinical Trials.

ABSTRACT:

Importance

Adjuvant drugs are used to reduce the risk of tumor recurrence in patients with cancer who are successfully treated with first-line therapy. The same drugs used in the metastatic or first-line setting are often used in the adjuvant setting, and although the resulting adverse effects may be similar between the 2 settings, tolerability may be different.

Objective

To compare the discontinuation rates of drugs in the adjuvant setting and in the metastatic setting in clinical trials of cancer drugs.

Design, setting, and participants

This cross-sectional study examined clinical trials of cancer drugs with results published in major medical and oncology journals between July 2018 through June 2021. Because adjuvant drugs can be used in a metastatic setting, includ

SUBMITTER: Ahmed N 

PROVIDER: S-EPMC9112068 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature