Survival Outcomes Associated With Cytoreductive Nephrectomy in Patients With Metastatic Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Importance

Level I evidence has failed to demonstrate an overall survival (OS) advantage for cytoreductive nephrectomy in patients with metastatic clear cell renal cell carcinoma (ccRCC) in the modern era, which is at odds with observational studies reporting a marked OS benefit associated with these operations. These observational studies were not designed to adjust for unmeasured confounding.

Objective

To assess whether cytoreductive nephrectomy is associated with improved OS in patients with metastatic ccRCC.

Design, setting, and participants

This cohort study identified patients with metastatic ccRCC in the National Cancer Database from January 1, 2006, to December 31, 2016, who received systemic targeted therapy. The analysis was finalized on July 23, 2021.

Ex

SUBMITTER: Chakiryan NH 

PROVIDER: S-EPMC9112069 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature