PI3K/AKT/mTOR Pathway-Associated Genes Reveal a Putative Prognostic Signature Correlated with Immune Infiltration in Hepatocellular Carcinoma.

ABSTRACT:

Background

The dysregulated PI3K/AKT/mTOR pathway acts as the main regulator of tumorigenesis in hepatocellular carcinoma (HCC).

Aim

Here, we identify the prognostic significance of PI3K/AKT/mTOR pathway-associated genes (PAGs) as well as their putative signature based on PAGs in an HCC patient's cohort.

Methods

The transcriptomic data and clinical feature sets were queried to extract the putative prognostic signature.

Results

We identified nine PAGs with different expressions. GO and KEGG indicated that these differentially expressed genes were associated with various carcinogenic pathways. Based on the signature-computed median risk score, we categorized the patients into groups of low risk and high risk. The survival time for the low-risk group is longer tha

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9112180 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature