Environmentally Responsible and Cost-Effective Synthesis of the Antimalarial Drug Pyronaridine.

ABSTRACT: Two routes to the antimalarial drug Pyronaridine are described. The first is a linear sequence that includes a two-step, one-pot transformation in an aqueous surfactant medium, leading to an overall yield of 87%. Alternatively, a convergent route utilizes a telescoped three-step sequence involving an initial neat reaction, followed by two steps performed under aqueous micellar catalysis conditions affording Pyronaridine in 95% overall yield. Comparisons to existing literature performed exclusively in organic solvents reveal a 5-fold decrease in environmental impact as measured by E Factors.

SUBMITTER: Kincaid JRA 

PROVIDER: S-EPMC9112334 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature