Increased expression of IL1-RL1 is associated with type 2 and type 1 immune pathways in asthma.

ABSTRACT:

Background

Asthma is a common chronic airway disease in the world. The purpose of this study was to explore the expression of IL1-RL1 in sputum and its correlation with Th1 and Th2 cytokines in asthma.

Methods

We recruited 132 subjects, detected IL1-RL1 protein level in sputum supernatant by ELISA, and analyzed the correlation between the expression level of IL1-RL1 and fraction of exhaled nitric oxide (FeNO), IgE, peripheral blood eosinophil count (EOS#), and Th2 cytokines (IL-4, IL-5, IL-10, IL-13, IL-33 and TSLP) and Th1 cytokines (IFN-γ, IL-2, IL-8). The diagnostic value of IL1-RL1 was evaluated by ROC curve. The expression of IL1-RL1 was further confirmed by BEAS-2B cell in vitro.

Results

Compared with the healthy control group, the expression of IL1-RL1 in sputu

SUBMITTER: Xu C 

PROVIDER: S-EPMC9112580 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature