The burden associated with, and management of, difficult-to-treat depression in patients under specialist psychiatric care in the United Kingdom.

ABSTRACT:

Background

Major depressive disorder (MDD) is common and often has sub-optimal response to treatment. Difficult-to-treat depression (DTD) is a new concept that describes 'depression that continues to cause significant burden despite usual treatment efforts'.

Aims

To identify patients with likely DTD in UK secondary care and examine demographic, disease and treatment data as compared with 'non-DTD' MDD patients.

Methods

Anonymised electronic health records (EHRs) of five specialist mental health National Health Service (NHS) Trusts in the United Kingdom were analysed using a natural language processing model. Data on disease characteristics, comorbidities and treatment histories were extracted from structured fields and using natural language algorithms from unstructur

SUBMITTER: Costa T 

PROVIDER: S-EPMC9112623 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature