The antidepressant effect and safety of non-intranasal esketamine: A systematic review.

ABSTRACT:

Background

The introduction of esketamine into the field of psychiatry comes on the heels of excitement from studies on racemic ketamine. While the intranasal route has been the most studied to date, other modes of administration of esketamine may also be of interest in the management of depression.

Aims

To systematically review the literature on non-intranasal esketamine for depression in terms of its antidepressant effect and safety.

Methods

We searched PubMed, Embase, the Cochrane Library, and Google Scholar from inception up to February 2021. Search terms included a combination of Medical Subject Headings and text words indicative of esketamine and depression. We selected both controlled and uncontrolled studies examining non-intranasal esketamine for the treatmen

SUBMITTER: Smith-Apeldoorn SY 

PROVIDER: S-EPMC9112628 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature