Thrombolytic Salvage of the Frostbitten Upper Extremity: A Systematic Review.

ABSTRACT:

Background

Vascular thrombosis secondary to frostbite can lead to ischemic tissue damage in severe cases. Threatened extremities may be salvaged with thrombolytics to restore perfusion; however, current data are limited to single institution case series. The authors performed a systematic review to determine the efficacy of thrombolytic therapy in treating upper extremity frostbite.

Methods

PubMed, EBSCO, and Google Scholar were queried using the keywords "thrombolytics," "frostbite," "fibrinolytics," and "tPA." Exclusion criteria were failure to delineate anatomic parts injured, failure to report number of limbs salvaged, animal studies, and non-English language publications. Thrombolytic therapy was defined as intraarterial (IA) or intravenous (IV) administration of tissue

SUBMITTER: Drinane J 

PROVIDER: S-EPMC9112743 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature