HaploMaker: An improved algorithm for rapid haplotype assembly of genomic sequences.

ABSTRACT:

Background

In diploid organisms, whole-genome haplotype assembly relies on the accurate identification and assignment of heterozygous single-nucleotide polymorphism alleles to the correct homologous chromosomes. This appropriate phasing of these alleles ensures that combinations of single-nucleotide polymorphisms on any chromosome, called haplotypes, can then be used in downstream genetic analysis approaches including determining their potential association with important phenotypic traits. A number of statistical algorithms and complementary computational software tools have been developed for whole-genome haplotype construction from genomic sequence data. However, many algorithms lack the ability to phase long haplotype blocks and simultaneously achieve a competitive accuracy.

SUBMITTER: Fruzangohar M 

PROVIDER: S-EPMC9112781 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature