Retrosplenial Cortex Effects Contextual Fear Formation Relying on Dysgranular Constituent in Rats.

ABSTRACT: Animal contextual fear conditioning (CFC) models are the most-studied forms used to explore the neural substances of posttraumatic stress disorder (PTSD). In addition to the well-recognized hippocampal-amygdalar system, the retrosplenial cortex (RSC) is getting more and more attention due to substantial involvement in CFC, but with a poor understanding of the specific roles of its two major constituents-dysgranular (RSCd) and granular (RSCg). The current study sought to identify their roles and underlying brain network mechanisms during the encoding processing of the rat CFC model. Rats with pharmacologically inactivated RSCd, RSCg, and corresponding controls underwent contextual fear conditioning. [¹⁸F]-fluorodeoxyglucose positron emission tomography/computed tomography (¹

SUBMITTER: Pan TT 

PROVIDER: S-EPMC9112855 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature