2-Methoxy-1,4-naphthoquinone regulated molecular alternation of Fusarium proliferatum revealed by high-dimensional biological data.

ABSTRACT: Fungi Fusarium proliferatum and the toxins it produces are hazardous to agricultural plants, animals, and human health. However, there is a lack of more effective and environment-friendly natural anti-F. proliferatum agents. In the search for natural anti-fungal agents, we found that naturally originated 2-methoxy-1,4-naphthoquinone (MNQ) with a minimal inhibitory dose of 8.0 mg L^-1 possessed a potential inhibitory effect on F. proliferatum. The results of transcriptomic, proteomic, and metabolomic reveal a total of 1314 differential expression genes (DEGs, 873 up-regulated and 441 down-regulated), 259 differential expression proteins (DEPs, 104 up-regulated and 155 down-regulated), and 86 differential accumulation metabolites (DAMs, 49 up-regulated and 37 d

SUBMITTER: Yang J 

PROVIDER: S-EPMC9112881 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature