Pseudomonas aeruginosa Initiates a Rapid and Specific Transcriptional Response during Surface Attachment.

ABSTRACT: Chronic biofilm infections by Pseudomonas aeruginosa are a major contributor to the morbidity and mortality of patients. The formation of multicellular bacterial aggregates, called biofilms, is associated with increased resistance to antimicrobials and immune clearance and the persistence of infections. Biofilm formation is dependent on bacterial cell attachment to surfaces, and therefore, attachment plays a key role in chronic infections. We hypothesized that bacteria sense various surfaces and initiate a rapid, specific response to increase adhesion and establish biofilms. RNA sequencing (RNA-Seq) analysis identified transcriptional changes of adherent cells during initial attachment, identifying the bacterial response to an abiotic surface over a 1-h period. Subsequent screens investiga

SUBMITTER: Jones CJ 

PROVIDER: S-EPMC9112911 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature