The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study.

ABSTRACT:

Aims

International guidelines mandate the use of fractional flow reserve (FFR) and/or non-hyperaemic pressure ratios to assess the physiological significance of moderate coronary artery lesions to guide revascularization decisions. However, they remain underused such that visual estimation of lesion severity continues to be the predominant decision-making tool. It would be pragmatic to have an improved understanding of the relationship between lesion morphology and haemodynamics. The aim of this study was to compute virtual FFR (vFFR) in idealized coronary artery geometries with a variety of stenosis and vessel characteristics.

Methods and results

Coronary artery geometries were modelled, based upon physiologically realistic branched arteries. Common stenosis characteristics

SUBMITTER: Newcombe RTF 

PROVIDER: S-EPMC9113079 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature