Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection.

ABSTRACT: The pathogenesis of atopic dermatitis (AD) results from complex interactions between environmental factors, barrier defects, and immune dysregulation resulting in systemic inflammation. Therefore, we sought to characterize circulating inflammatory profiles in pediatric AD patients and identify potential signaling nodes which drive disease heterogeneity and progression. We analyzed a sample set of 87 infants that were at high risk for atopic disease based on atopic dermatitis diagnoses. Clinical parameters, serum, and peripheral blood mononuclear cells (PBMCs) were collected upon entry, and at one and four years later. Within patient serum, 126 unique analytes were measured using a combination of multiplex platforms and ultrasensitive immunoassays. We assessed the correlation of inflammator

SUBMITTER: Engle SM 

PROVIDER: S-EPMC9113166 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature