Biphasic mineralized collagen-based composite scaffold for cranial bone regeneration in developing sheep.

ABSTRACT: Appropriate mechanical support and excellent osteogenic capability are two essential prerequisites of customized implants for regenerating large-sized cranial bone defect. Although porous bone scaffolds have been widely proven to promote bone regeneration, their weak mechanical properties limit the clinical applications in cranioplasty. Herein, we applied two previously developed mineralized collagen-based bone scaffolds (MC), porous MC (pMC) and compact MC (cMC) to construct a biphasic MC composite bone scaffold (bMC) to repair the large-sized cranial bone defect in developing sheep. A supporting frame composed of cMC phase in the shape of tic-tac-toe structure was fabricated first and then embedded in pMC phase. The two phases had good interfacial bond,

SUBMITTER: Zheng J 

PROVIDER: S-EPMC9113234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature