Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling.

ABSTRACT: Prefrontal cortex exerts control over sensory and motor systems via cross-frequency coupling. However, it is unknown whether these signals play a role in reward-based decision-making and whether such dynamic network configuration is altered in a major depressive episode. We recruited men and women with and without depression to perform a streamlined version of the Expenditure of Effort for Reward Task during recording of electroencephalography. Goal-directed behavior was quantified as willingness to exert physical effort to obtain reward, and reward-evaluation was the degree to which the decision to exert effort was modulated by incentive level. We found that the amplitude of frontal-midline theta oscillations was greatest in participants with the greatest reward-evaluation. Furthermore, c

SUBMITTER: Riddle J 

PROVIDER: S-EPMC9113280 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature