Vascular dysfunction and increased cardiovascular risk in hypospadias.

ABSTRACT:

Aims

Hypogonadism is associated with cardiovascular disease. However, the cardiovascular impact of hypogonadism during development is unknown. Using hypospadias as a surrogate of hypogonadism, we investigated whether hypospadias is associated with vascular dysfunction and is a risk factor for cardiovascular disease.

Methods and results

Our human study spanned molecular mechanistic to epidemiological investigations. Clinical vascular phenotyping was performed in adolescents with hypospadias and controls. Small subcutaneous arteries from penile skin from boys undergoing hypospadias repair and controls were isolated and functional studies were assessed by myography. Vascular smooth muscle cells were used to assess: Rho kinase, reactive oxygen species (ROS), nitric oxide synthas

SUBMITTER: Lucas-Herald AK 

PROVIDER: S-EPMC9113289 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature