Low-density lipoprotein cholesterol response after statin initiation among persons living with human immunodeficiency virus.

ABSTRACT:

Background

Meta-analyses of general population studies report mean low-density lipoprotein cholesterol (LDL-C) reductions of 30% to <50% with moderate-intensity and ≥50% with high-intensity statins. Persons living with human immunodeficiency virus (PLWH) are at high risk for atherosclerotic cardiovascular disease (ASCVD), yet many have elevated LDL-C.

Objective

To evaluate LDL-C response after statin initiation among PLWH.

Methods

We conducted a retrospective cohort study of PLWH initiating statins between 2009 and 2013 (N = 706). Patients were categorized into mutually exclusive groups in the following hierarchy: history of coronary heart disease (CHD), diabetes, prestatin LDL-C ≥190 mg/dL, 10-year predicted ASCVD risk ≥7.5%, and none of the above (ie, unknown statin

SUBMITTER: Burkholder GA 

PROVIDER: S-EPMC9113294 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature