Functional analysis of the stable phosphoproteome reveals cancer vulnerabilities.

ABSTRACT:

Motivation

The advance of mass spectrometry-based technologies enabled the profiling of the phosphoproteomes of a multitude of cell and tissue types. However, current research primarily focused on investigating the phosphorylation dynamics in specific cell types and experimental conditions, whereas the phosphorylation events that are common across cell/tissue types and stable regardless of experimental conditions are, so far, mostly ignored.

Results

Here, we developed a statistical framework to identify the stable phosphoproteome across 53 human phosphoproteomics datasets, covering 40 cell/tissue types and 194 conditions/treatments. We demonstrate that the stably phosphorylated sites (SPSs) identified from our statistical framework are evolutionarily conserved, functionally

SUBMITTER: Xiao D 

PROVIDER: S-EPMC9113330 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature