Driver gene detection through Bayesian network integration of mutation and expression profiles.

ABSTRACT:

Motivation

The identification of mutated driver genes and the corresponding pathways is one of the primary goals in understanding tumorigenesis at the patient level. Integration of multi-dimensional genomic data from existing repositories, e.g., The Cancer Genome Atlas (TCGA), offers an effective way to tackle this issue. In this study, we aimed to leverage the complementary genomic information of individuals and create an integrative framework to identify cancer-related driver genes. Specifically, based on pinpointed differentially expressed genes, variants in somatic mutations and a gene interaction network, we proposed an unsupervised Bayesian network integration (BNI) method to detect driver genes and estimate the disease propagation at the patient and/or cohort levels. This ne

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9113331 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature