CBNplot: Bayesian network plots for enrichment analysis.

ABSTRACT:

Summary

When investigating gene expression profiles, determining important directed edges between genes can provide valuable insights in addition to identifying differentially expressed genes. In the subsequent functional enrichment analysis (EA), understanding how enriched pathways or genes in the pathway interact with one another can help infer the gene regulatory network (GRN), important for studying the underlying molecular mechanisms. However, packages for easy inference of the GRN based on EA are scarce. Here, we developed an R package, CBNplot, which infers the Bayesian network (BN) from gene expression data, explicitly utilizing EA results obtained from curated biological pathway databases. The core features include convenient wrapping for structure learning, visualization

SUBMITTER: Sato N 

PROVIDER: S-EPMC9113354 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature