BSDE: barycenter single-cell differential expression for case-control studies.

ABSTRACT:

Motivation

Single-cell sequencing brings about a revolutionarily high resolution for finding differentially expressed genes (DEGs) by disentangling highly heterogeneous cell tissues. Yet, such analysis is so far mostly focused on comparing between different cell types from the same individual. As single-cell sequencing becomes cheaper and easier to use, an increasing number of datasets from case-control studies are becoming available, which call for new methods for identifying differential expressions between case and control individuals.

Results

To bridge this gap, we propose barycenter single-cell differential expression (BSDE), a nonparametric method for finding DEGs for case-control studies. Through the use of optimal transportation for aggregating distributions and comp

SUBMITTER: Zhang M 

PROVIDER: S-EPMC9113363 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature