Radiation dose to circumscribed brain regions and neurocognitive function in patients with meningioma.

ABSTRACT:

Background

Although radiation (RT) is standard treatment for many brain tumors, it may contribute to neurocognitive decline. The objective of this study was to investigate associations between RT dose to circumscribed brain regions and specific neurocognitive domains in patients with meningioma.

Methods

We undertook a retrospective study of 40 patients with meningioma who received RT and underwent an in-depth clinical neurocognitive assessment. Radiation dosimetry characteristics were delineated based on treatment planning computerized tomography co-registered with contrast-enhanced 3D T1-weighted magnetic resonance imaging. Principal components analysis was applied to organize neurocognitive test scores into factors, and multivariate multiple linear regression models were u

SUBMITTER: Sekely A 

PROVIDER: S-EPMC9113401 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature