Mg(OH)₂ nanosheets on Ti with immunomodulatory function for orthopedic applications.

ABSTRACT: Macrophages play a vital role for guiding the fate of osteogenesis- related cells. It is well known that nano-topography and bioactive ions can directly enhance osteogenic behavior. However, the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely reported. Herein, Mg(OH)₂ films with nano-sheet structures were constructed on the surface of Ti using hydrothermal treatment. The film presented nano-sheet topography and sustained release of Mg ions. The results of in vitro culture of bone marrow-derived macrophages (BMDMs), including PCR, western blot and flow cytometry suggested that the nano-Mg(OH)₂ films were more favorable for macrophages polarizing to tissue healing

SUBMITTER: He Y 

PROVIDER: S-EPMC9113411 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature