Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain.

ABSTRACT: Significance: The glymphatic system has been described recently as a series of perivascular channels that facilitate fluid exchange and solute clearance in the brain. Glymphatic dysfunction has been implicated in numerous pathological conditions, including Alzheimer's disease, traumatic brain injury, and stroke. Existing methods for assessing glymphatic function have been challenging: dynamic methods, such as two-photon microscopy and contrast-enhanced magnetic resonance imaging require expensive instrumentation and specific technical skills; slice-based fluorescent imaging is more readily implemented but lacks temporal resolution. Aim: To develop a straightforward and adaptable dynamic imaging approach for assessing glymphatic function in vivo in mice. Approach:

SUBMITTER: Keil SA 

PROVIDER: S-EPMC9113559 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature