Polymorphisms and avascular necrosis in patients with sickle cell disease - A systematic review.

ABSTRACT:

Objective

To systematically establish whether there is an association between polymorphisms and avascular necrosis in patients with sickle cell disease.

Data source

The review, conducted according to PRISMA guidelines and registered with PROSPERO, was based on research of studies in PubMed, SciELO, LILACS, BVS databases and in the gray literature (Google Scholar and Open Gray) published until June 2020. The STROBE initiative was used to analyze the articles' quality.

Data synthesis

Ten articles were selected from the databases and two were included through manual search, totaling 12 studies. All samples gathered 2,362 patients. According to STROBE, seven studies fully and/or partially covered more than 70% of the essential items and two studies reached less than 60%,

SUBMITTER: Leandro MP 

PROVIDER: S-EPMC9113627 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature