Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging.

ABSTRACT: Internephron interaction is fundamental for kidney function. Earlier studies have shown that nephrons signal to each other, synchronize over short distances, and potentially form large synchronized clusters. Such clusters would play an important role in renal autoregulation, but due to the technological limitations, their presence is yet to be confirmed. In the present study, we introduce an approach for high-resolution laser speckle imaging of renal blood flow and apply it to estimate the frequency and phase differences in rat kidney microcirculation under different conditions. The analysis unveiled the spatial and temporal evolution of synchronized blood flow clusters of various sizes, including the formation of large (>90 vessels) and long-lived clusters (>10 periods) locked at the freq

SUBMITTER: Postnov D 

PROVIDER: S-EPMC9113743 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature