Gut Microbiome Was Highly Related to the Regulation of Metabolism in Lung Adenocarcinoma Patients.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most predominant subtypes of lung cancer. The gut microbiome plays a vital role in the pathophysiological processes of various diseases, including cancers.

Methods

In the study, 100 individuals were enrolled. In total 75 stool and blood samples were analyzed with 16s-rRNA gene sequencing and metabolomics (30 from healthy individuals (H); 45 from LUAD patients). In addition, 25 stool samples were analyzed with metagenomics (10 from H; 15 from LUAD). The linear discriminant analysis (LDA) effect size (LefSe) and logistic regression analysis were applied to identify biomarkers' taxa and develop a diagnostic model. The diagnostic power of the model was estimated with the receiver operating characteristic curve (ROC) by comparin

SUBMITTER: Wang S 

PROVIDER: S-EPMC9113755 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature