Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study.

ABSTRACT:

Context

Observational studies have suggested associations between adipokines and cardiovascular disease (CVD), but the roles of certain adipokines remain controversial, and these associations have not yet been ascertained causally.

Objective

To investigate whether circulating adipokines causally affect the risk of CVD using 2-sample Mendelian randomization (MR).

Methods

Independent genetic variants strongly associated with adiponectin, resistin, chemerin, and retinol binding protein 4 (RBP4) were selected from public genome-wide association studies. Summary-level statistics for CVD, including coronary artery disease (CAD), myocardial infarction, atrial fibrillation (AF), heart failure (HF), and stroke and its subtypes were collected. The inverse-variance weighted and

SUBMITTER: Chen D 

PROVIDER: S-EPMC9113792 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature