Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.

ABSTRACT:

Context

Osteoporosis results from disturbances in bone formation and resorption. Recent nonhuman data suggest that the reproductive hormone kisspeptin directly stimulates osteoblast differentiation in vitro and thus could have clinical therapeutic potential. However, the effects of kisspeptin on human bone metabolism are currently unknown.

Objective

To assess the effects of kisspeptin on human bone metabolism in vitro and in vivo.

Methods

In vitro study: of Mono- and cocultures of human osteoblasts and osteoclasts treated with kisspeptin. Clinical study: Randomized, placebo-controlled, double-blind, 2-way crossover clinical study in 26 men investigating the effects of acute kisspeptin administration (90 minutes) on human bone metabolism, with blood sampling every 30 m

SUBMITTER: Comninos AN 

PROVIDER: S-EPMC9113799 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature