Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females.

ABSTRACT:

Context

Cold exposure mobilizes lipids to feed thermogenic processes in organs, including brown adipose tissue (BAT). In rodents, BAT metabolic activity exhibits a diurnal rhythm, which is highest at the start of the wakeful period.

Objective

We investigated whether cold-induced thermogenesis displays diurnal variation in humans and differs between the sexes.

Methods

This randomized crossover study included 24 young and lean male (n = 12) and female (n = 12) participants who underwent 2.5-hour personalized cooling using water-perfused mattresses in the morning (7:45 am) and evening (7:45 pm), with 1 day in between. We measured energy expenditure (EE) and supraclavicular skin temperature in response to cold exposure.

Results

In males, cold-induced EE was higher

SUBMITTER: Straat ME 

PROVIDER: S-EPMC9113803 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature