Ontology highlight
ABSTRACT:
SUBMITTER: Saliani M
PROVIDER: S-EPMC9113938 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Saliani Mahsa M Mirzaiebadizi Amin A Javadmanesh Ali A Siavoshi Akram A Ahmadian Mohammad Reza MR
Cancer gene therapy 20210906 5
KRAS is one of the most widely prevalent proto-oncogenes in human cancers. The constitutively active KRAS oncoprotein contributes to both tumor onset and cancer development by promoting cell proliferation and anchorage-independent growth in a MAPK pathway-dependent manner. The expression of microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, while long noncoding RNAs (lncRNAs) can act as regulators of the miRNAs targeting KRAS oncogene in different cancers a ...[more]