Life events and treatment prognosis for depression: A systematic review and individual patient data meta-analysis.

ABSTRACT:

Objective

To investigate associations between major life events and prognosis independent of treatment type: (1) after adjusting for clinical prognostic factors and socio-demographics; (2) amongst patients with depressive episodes at least six-months long; and (3) patients with a first life-time depressive episode.

Methods

Six RCTs of adults seeking treatment for depression in primary care met eligibility criteria, individual patient data (IPD) were collated from all six (n = 2858). Participants were randomized to any treatment and completed the same baseline assessment of life events, demographics and clinical prognostic factors. Two-stage random effects meta-analyses were conducted.

Results

Reporting any major life events was associated with poorer prognosis regardl

SUBMITTER: Buckman JEJ 

PROVIDER: S-EPMC9113943 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature