Expression regulation of genes is linked to their CpG density distributions around transcription start sites.

ABSTRACT: The CpG dinucleotide and its methylation behaviors play vital roles in gene regulation. Previous studies have divided genes into several categories based on the CpG intensity around transcription starting sites and found that housekeeping genes tend to possess high CpG density, whereas tissue-specific genes are generally characterized by low CpG density. In this study, we investigated how the CpG density distribution of a gene affects its transcription and regulation pattern. Based on the CpG density distribution around transcription starting site, by means of a semi-supervised neural network we designed, which took data augmentation into account, we divided the human genes into three categories, and genes within each cluster shared similar CpG density distribution. Not only sequence prope

SUBMITTER: Tian H 

PROVIDER: S-EPMC9113945 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature