Discontinuation of adjuvant endocrine therapy and impact on quality of life and functional status in older patients with breast cancer.

ABSTRACT:

Purpose

Side effects are the main reason for discontinuation of adjuvant endocrine therapy in older adults. The aim of this study was to examine geriatric predictors of treatment discontinuation of adjuvant endocrine therapy within the first 2 years after initiation, and to study the association between early discontinuation and functional status and quality of life (QoL).

Methods

Patients aged ≥ 70 years with stage I-III breast cancer who received adjuvant endocrine therapy were included. The primary endpoint was discontinuation of endocrine therapy within 2 years. Risk factors for discontinuation were assessed using univariate logistic regression models. Linear mixed models were used to assess QoL and functional status over time.

Results

Overall, 258 patients were i

SUBMITTER: Lemij AA 

PROVIDER: S-EPMC9114046 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature