Early stage breast cancer follow-up in real-world clinical practice: the added value of cell free circulating tumor DNA.

ABSTRACT:

Purpose

Physical examinations and annual mammography (minimal follow-up) are as effective as laboratory/imaging tests (intensive follow-up) in detecting breast cancer (BC) recurrence. This statement is now challenged by the availability of new diagnostic tools for asymptomatic cases. Herein, we analyzed current practices and circulating tumor DNA (ctDNA) in monitoring high-risk BC patients treated with curative intent in a comprehensive cancer center.

Patients and methods

Forty-two consecutive triple negative BC patients undergoing neoadjuvant therapy and surgery were prospectively enrolled. Data from plasma samples and surveillance procedures were analyzed to report the diagnostic pattern of relapsed cases, i.e., by symptoms, follow-up procedures and ctDNA.

Results

B

SUBMITTER: La Rocca E 

PROVIDER: S-EPMC9114063 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature